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An early monomeric dual receptor agonist targeted both GLP-1R and GIPR, and the synergism between the two receptor systems was initially reported 10 years ago
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Indeed, in silico molecular docking study regarding the DPP4/CTNNB1/MET signatures showed that stagliptin could be a potential TC drug, however more investigations are surely needed to confirm it ( Gemigliptin Gemigliptin is an orally bioavailable inhibitor of DPP-4, with hypoglycemic and potential renoprotective activities
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